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Skin-Specific Outcomes of Brepocitinib in Dermatomyositis: Evidence from a Phase 3 Randomized Clinical Trial and Secondary Analysis

Brepocitinib, a selective TYK2-JAK1 inhibitor, showed rapid, sustained skin disease control, itch relief, and improved quality of life in dermatomyositis patients over 52 weeks with an acceptable safety profile in a global phase 3 trial.

Sep 3, 2026
Dermatology

Serum Amyloid A as a Prognostic Biomarker in Dermatomyositis-Associated Rapidly Progressive Interstitial Lung Disease

Elevated serum amyloid A correlates with rapidly progressive interstitial lung disease and mortality in dermatomyositis, with combined assessment alongside anti-MDA5 antibody improving risk stratification.

Sep 3, 2026
Dermatology

The TIP-CA Model: A Validated Tool to Stratify Cancer Risk in Adult Dermatomyositis Patients

Researchers have developed and validated the TIP-CA model, a clinical tool using five key factors—anti-TIF1-γ, ILD absence, poikiloderma, DM subtype, and anemia—to accurately predict malignancy risk in patients with dermatomyositis, enablin

Mar 4, 2026

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