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Strategic Release of Wolbachia-Infected Mosquitoes Reduces Dengue Risk by Over 70% in Urban Singapore
Infectious DiseasesDenguepublic health

Strategic Release of Wolbachia-Infected Mosquitoes Reduces Dengue Risk by Over 70% in Urban Singapore

By MedXY|Feb 22, 2026

A large-scale cluster-randomized trial in Singapore demonstrates that releasing male Aedes aegypti mosquitoes infected with the wAlbB Wolbachia strain significantly suppresses wild-type populations and reduces the incidence of symptomatic d

Daily High‑Dose Mosnodenvir Significantly Lowers DENV‑3 Viremia in a Human Challenge — Proof‑of‑Concept with Early Resistance Signals
Infectious Diseasesantiviral prophylaxisDengue

Daily High‑Dose Mosnodenvir Significantly Lowers DENV‑3 Viremia in a Human Challenge — Proof‑of‑Concept with Early Resistance Signals

By MedXY|Nov 27, 2025

In a phase 2a human challenge, high‑dose daily mosnodenvir substantially reduced DENV‑3 RNA burden versus placebo without serious adverse events, but treatment‑associated NS4B viral mutations emerged, highlighting efficacy and resistance co

DEN-CORE: An international consensus COMS to standardise dengue clinical trials
Infectious Diseasesclinical trialsDengue

DEN-CORE: An international consensus COMS to standardise dengue clinical trials

By MedXY|Nov 23, 2025

An international Delphi consensus defined a Core Outcome Measurement Set (COMS) for dengue trials to harmonise outcome selection and measurement across settings, improving comparability and evidence synthesis.

Cardiovascular Risks in Acute Dengue Infection: Insights from a Large Population-Based Cohort Study
CardiologyCardiovascular ComplicationsDengue

Cardiovascular Risks in Acute Dengue Infection: Insights from a Large Population-Based Cohort Study

By MedXY|Oct 30, 2025

A comprehensive Singaporean cohort study reveals increased odds of cardiovascular complications during the first 30 days post-acute dengue infection, especially in older adults, emphasizing the need for targeted cardiac monitoring.

Efficacy and Challenges of Targeted Indoor Residual Spraying for Aedes-Borne Virus Prevention: Insights from a Cluster-Randomized Trial
Infectious DiseasesDengueindoor residual spraying

Efficacy and Challenges of Targeted Indoor Residual Spraying for Aedes-Borne Virus Prevention: Insights from a Cluster-Randomized Trial

By MedXY|Oct 25, 2025

This study evaluates targeted indoor residual spraying’s effectiveness against Aedes-borne diseases and highlights its limitations despite entomologic success.

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