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A large-scale cluster-randomized trial in Singapore demonstrates that releasing male Aedes aegypti mosquitoes infected with the wAlbB Wolbachia strain significantly suppresses wild-type populations and reduces the incidence of symptomatic d
In a phase 2a human challenge, high‑dose daily mosnodenvir substantially reduced DENV‑3 RNA burden versus placebo without serious adverse events, but treatment‑associated NS4B viral mutations emerged, highlighting efficacy and resistance co
An international Delphi consensus defined a Core Outcome Measurement Set (COMS) for dengue trials to harmonise outcome selection and measurement across settings, improving comparability and evidence synthesis.
A comprehensive Singaporean cohort study reveals increased odds of cardiovascular complications during the first 30 days post-acute dengue infection, especially in older adults, emphasizing the need for targeted cardiac monitoring.
This study evaluates targeted indoor residual spraying’s effectiveness against Aedes-borne diseases and highlights its limitations despite entomologic success.
