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Association Between Menopausal Hormone Therapy and Alzheimer Disease Neuropathology: Insights from Large Cohort Studies
Clinical Updatesdementia riskneuropathology

Association Between Menopausal Hormone Therapy and Alzheimer Disease Neuropathology: Insights from Large Cohort Studies

By MedXY|Aug 18, 2026

This review synthesizes recent evidence linking menopausal hormone therapy (MHT), particularly estrogen-only regimens, with decreased Alzheimer disease neuropathology and clinical dementia risk, highlighting biomarker correlations, clinical

Decoding Sleep’s Role in Cognitive Health and Dementia Risk: Insights from the Sleep and Dementia Consortium
Neurologycognition
cognitive performance

Decoding Sleep’s Role in Cognitive Health and Dementia Risk: Insights from the Sleep and Dementia Consortium

By MedXY|Jul 31, 2026

This study identifies distinct sleep patterns linked to cognitive performance but finds no significant direct association with dementia risk, highlighting the complexity of sleep-cognition relationships in aging populations.

Optimal Sleep Duration Mitigates Cognitive Decline and Dementia Risk in Focal Epilepsy: Insights from the UK Biobank Study
Neurologycognitive functiondementia risk

Optimal Sleep Duration Mitigates Cognitive Decline and Dementia Risk in Focal Epilepsy: Insights from the UK Biobank Study

By MedXY|Apr 25, 2026

A UK Biobank study reveals that optimal sleep (6-8 hours) improves executive function and reduces dementia risk in focal epilepsy patients, with effects surpassing those in stroke patients. Nonoptimal sleep exacerbates cognitive deficits up

High-Sensitivity Cardiac Troponins and Dementia Risk: Insights from Longitudinal Cohort Studies
CardiologybiomarkersCardiac troponin

High-Sensitivity Cardiac Troponins and Dementia Risk: Insights from Longitudinal Cohort Studies

By MedXY|Nov 28, 2025

Elevated high-sensitivity cardiac troponin I and T levels, indicative of subclinical myocardial injury in midlife, are associated with accelerated cognitive decline, structural brain changes, and increased dementia risk in later life.

Environmental and Social Injustices Elevate Dementia Risk in Older Adults with End-Stage Kidney Disease: Insights from a National Registry Study
Nephrologydementia riskhealth disparities

Environmental and Social Injustices Elevate Dementia Risk in Older Adults with End-Stage Kidney Disease: Insights from a National Registry Study

By MedXY|Oct 29, 2025

This national registry study reveals that older adults with end-stage kidney disease (ESKD) exposed to high fine particulate pollution and racial/ethnic segregation face significantly elevated dementia risk, highlighting critical environmen

How Poor Sleep Accelerates Brain Aging: The Role of Inflammation and What You Can Do
Neurologycognitive healthdementia risk

How Poor Sleep Accelerates Brain Aging: The Role of Inflammation and What You Can Do

By MedXY|Oct 8, 2025

New research links poor sleep quality in middle-aged and older adults to accelerated brain aging, with inflammation playing a key role. Improving sleep may help slow cognitive decline and promote brain health.

Childhood Loneliness: A Lasting Risk Factor for Cognitive Decline and Dementia in Later Life
Clinical Updatescognitive declinedementia risk

Childhood Loneliness: A Lasting Risk Factor for Cognitive Decline and Dementia in Later Life

By MedXY|Oct 9, 2025

Childhood loneliness significantly increases the risk of cognitive decline and dementia in middle-aged and older adults, independent of adult loneliness, highlighting the importance of early psychosocial interventions.

Precision Nutrition: Can the Mediterranean Diet Reduce Alzheimer’s Risk in APOE4 Carriers?
Family Medicine & NutritionAlzheimer's diseaseAPOE4

Precision Nutrition: Can the Mediterranean Diet Reduce Alzheimer’s Risk in APOE4 Carriers?

By MedXY|Oct 6, 2025

A large prospective study reveals that adherence to a Mediterranean diet significantly lowers dementia risk, especially in individuals carrying two copies of the APOE4 gene associated with Alzheimer’s disease, highlighting the potential of

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