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This review synthesizes evidence on how individual patient characteristics modify the comparative effects of cefepime versus piperacillin-tazobactam on acute kidney injury and neurologic outcomes in adults hospitalized with acute infection.
RCT evidence shows that restrictive low-use versus liberal high-use physical restraint strategies in mechanically ventilated ICU patients do not differ in days alive without delirium or coma at 14 days.
A pragmatic RCT in an Australian ICU found the ABCDEF bundle did not reduce delirium incidence or duration but improved patients’ ability to perform usual activities at 90 days post-discharge, suggesting possible long-term quality of
A large single-center study found that hospitalized patients with limited English proficiency had higher adjusted odds of physical restraint or antipsychotic use, especially when delirium was present, raising concerns about communication-dr
A large multisite cohort found delirium in 16% of older adults in the emergency department, including nearly 8% of those discharged, with strong links to dementia, acuity, hospitalization, and 30-day readmission.
A large multi-site cohort found delirium in 16% of older ED patients, including many discharged home, and linked it to higher admission and 30-day readmission, underscoring the need for standardized screening and supportive care.
A new study highlights significant disparities in delirium detection for Spanish-speaking ICU patients, with usual-care methods missing 72% of cases. Caregiver-administered tools improved detection by 47%, offering a potential solution to l
A large-scale matched cohort study from the UK Biobank identifies in-hospital delirium as a sentinel marker for long-term multisystem vulnerability. Associated with increased risks of sepsis, AKI, and falls, delirium signals a profound phys
A large-scale cross-sectional study of 51,202 admissions reveals that 35.6% of patients aged 70 and older experience cognitive morbidity, predominantly delirium. The findings underscore the urgent necessity for hospital-wide screening and m
A recent systematic review and meta-analysis of 13 randomized controlled trials concludes that melatonin fails to reduce the incidence of delirium or mortality in critically ill patients, challenging the routine use of this supplement in th
The DEMEL trial found that while 0.3 mg of melatonin achieved a superior pharmacokinetic profile over 3 mg, it failed to reduce delirium incidence or improve clinical outcomes in mechanically ventilated patients compared to placebo.
This multicenter longitudinal study reveals that delusional memories, rather than simple amnesia, are the primary predictors of persistent PTSD symptoms following critical illness, highlighting the critical roles of delirium and sedation in
A multicenter randomized trial reveals that a brief, structured training intervention for emergency physicians significantly increases the use of ultrasound-guided fascia iliaca blocks, resulting in a 28% reduction in delirium risk for geri
A predictive model combining bedside nurse ICDSC items and clinical variables (ventilation, SOFA) substantially improves agreement with researcher CAM-ICU assessments, enabling more accurate, scalable delirium ascertainment in ICU research
This 10-year study from England details delirium’s prevalence, associated factors like dementia and frailty, and its lasting impact on mortality and care needs in acute general medicine patients, supporting targeted screening and inte
