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Phase 2 PLATCOV results show oral ensitrelvir accelerates SARS‑CoV‑2 clearance versus no drug and has antiviral effects close to ritonavir‑boosted nirmatrelvir, supporting further phase 3 evaluation.
Transcriptomic deconvolution of blood identifies elevated circulating endothelial signatures (ECS%) that associate with higher 28‑day mortality and worse respiratory trajectories in pediatric respiratory failure and adults hospitalized with
A Spanish multicenter study reveals a sharp rise in pediatric invasive group A streptococcal infections and severity after 2022, highlighting emm1 strain predominance and risk factors for critical illness and mortality.
This study evaluates clinical testing trends for COVID-19, influenza, and RSV among hospitalized children from 2016 to 2024, revealing shifts in testing frequency and identifying factors influencing test utilization.
The GBD 2023 Study integrates data from 204 countries to reveal shifting global mortality patterns, emphasizing the impact of COVID-19, declining vaccine-preventable deaths, and rising non-communicable diseases, highlighting critical areas
This review synthesizes recent evidence from the ACTIV-6 trial showing metformin does not significantly reduce symptom duration in low-risk adults with COVID-19, addressing safety, clinical outcomes, and translational insights.
The FDA has authorized updated COVID-19 vaccines from Pfizer and Moderna designed to target the LP.8.1 sublineage, expanding vaccination to adults over 65 and individuals with high-risk conditions, enhancing immune defense against evolving
A survey reveals significant increases in depression and anxiety rates among various racial groups during the COVID-19 pandemic, highlighting ongoing racial health disparities.
Kidney-transplant recipients on long-term kidney replacement therapy demonstrate significant reductions in COVID-19-related hospitalizations and mortality following three or more vaccine doses, supporting booster vaccinations in this vulner
Recent rhinovirus infection may nearly halve COVID-19 risk and reduce viral load by triggering airway antiviral gene expression, partially explaining children’s milder COVID-19 outcomes.
A recent Irish study reveals that 6 in 10 healthcare workers with respiratory symptoms test for COVID-19, while vaccination coverage remains low, highlighting ongoing risks and the need for enhanced infection control and vaccination strateg
Observational data from the RECOVER Initiative suggest that SARS-CoV-2 reinfection raises the risk of long COVID by 35% relative to single infections, with more recent vaccination potentially mitigating this risk.
COVID-19 accelerates vascular aging by approximately 5 years, disproportionately affecting women, with vaccination conferring protection primarily in females, highlighting sex-specific immunological responses and long-term vascular risks.
The Stratus variant, known as XFG, now dominates COVID-19 cases in the U.S., complicating recovery efforts amidst rising infections and changing vaccine guidance.
The CDC no longer universally recommends COVID-19 vaccination during pregnancy, prompting debate among clinicians as the FDA shifts vaccine composition to target the JN.1 variant. This article analyzes the evidence, rationale, and clinical
