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Differential Gastrointestinal Risks of Opioids in Type 2 Diabetes Patients on GLP-1RA Therapy: A Comparative Analysis

Among type 2 diabetes patients using GLP-1 receptor agonists, oxycodone is linked to higher short-term risks of severe gastrointestinal complications compared to hydrocodone and tramadol, warranting cautious opioid selection in this populat

Sep 15, 2026Sign in to read

Gastroenterology

FDA Approves Linzess for Pediatric IBS with Constipation: A New Hope for Children

The FDA has approved linaclotide (Linzess) for treating irritable bowel syndrome with constipation (IBS-C) in children 7 and older, marking the first official treatment option for pediatric IBS-C.

Nov 6, 2025

Gastroenterology

Gastrointestinal Burden in CHARGE Syndrome: High Prevalence of Constipation, Age-Related Patterns, and Quality‑of‑Life Impact

In a cohort of 50 individuals with CHARGE syndrome, GI problems affected 64% and constipation 48%, with constipation associated with lower PedsQL GI scores and greater comorbidity; younger patients had more diverse GI issues while older pat

Nov 4, 2025Sign in to read