comparative effectiveness

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Evaluating GLP-1 Receptor Agonists Versus Oral Agents for Insulin Discontinuation in Type 2 Diabetes: Insights from a Veterans Health Administration Target Trial Emulation

A large study in veterans with type 2 diabetes found that adding GLP-1 receptor agonists to basal insulin did not improve insulin discontinuation rates compared to SGLT-2 inhibitors or DPP-4 inhibitors over three years.

Aug 3, 2026Sign in to read

Respiratory

Oral Appliances Found Non-Inferior to CPAP for Sleep Apnea in Sequential Effectiveness Study

A prospective non-randomized study found mandibular advancement devices non-inferior to CPAP in a combined efficacy-adherence measure (MDA), with higher nightly adherence and patient preference, but study design limits interpretation.

Jul 27, 2026Sign in to read

Cardiology

No Clear Winner: Real-World Evidence Shows GLP-1RAs and SGLT2 Inhibitors Deliver Comparable Cardiovascular Benefits in Type 2 Diabetes

A large-scale multinational study of over 1.2 million patients reveals that individual GLP-1 receptor agonists and SGLT2 inhibitors offer broadly similar cardiovascular protection in type 2 diabetes, challenging assumptions about meaningful

Apr 18, 2026