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A landmark one-year actigraphy study reveals that sleep phase variability and daily activity amplitude are significant objective markers for predicting MDD relapse, offering a scalable path toward personalized, preventive psychiatric care.
In a mouse spared nerve injury model, pregabalin—but not morphine—restored REM sleep, normalized locomotor and temperature circadian rhythms, and reversed spinal circadian gene changes. Findings suggest analgesic choice can differentially a
Emerging evidence links WFS1-driven ER stress to serotonergic/cholinergic disruption, executive dysfunction, and circadian dysregulation in Wolfram syndrome. This article synthesizes recent data, outlines chrono‑informed clinical assessment
