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Chronic Myeloid Leukemia

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Hematology-Oncology

Asciminib as a Robust Treatment Option for BCR::ABL1 T315I-Mutated Chronic Myeloid Leukemia: Final Phase 1 Trial Outcomes

Long-term phase 1 data confirm asciminib’s efficacy and safety in treating CML-CP patients harboring the resistant BCR::ABL1 T315I mutation, with sustained major molecular responses and manageable adverse events over nearly six years.

Sep 18, 2026Sign in to read
Hematology-Oncology

Unraveling Molecular Mechanisms in Chronic Myeloid Leukemia: Insights from the EURO-SKI Biomarker Study on Treatment-Free Remission and Relapse

The EURO-SKI Biomarker Study elucidates molecular signatures and immune interactions underlying treatment-free remission and relapse in chronic myeloid leukemia patients discontinuing tyrosine kinase inhibitors, highlighting immune communic

Jun 25, 2026
Clinical Updates

Ribosome Collisions and the ZAK-Dependent Ribotoxic Stress Response: A Novel Therapeutic Vulnerability in Chronic Myeloid Leukemia

This review synthesizes evidence that BCR::ABL1 inhibitors induce ribosome collisions and ZAK-dependent apoptosis, highlighting the ribotoxic stress response as a critical pathway for TKI efficacy and a potential target to overcome resistan

Apr 3, 2026

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