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Predictive Biomarkers in PML: Preexisting Virus-Specific T Cells as Determinants of Response to Checkpoint Inhibition
Clinical UpdatesCheckpoint InhibitorsT細胞免疫学

Predictive Biomarkers in PML: Preexisting Virus-Specific T Cells as Determinants of Response to Checkpoint Inhibition

By MedXY|Mar 13, 2026

This review synthesizes recent evidence on the role of pretreatment virus-specific T cells in predicting clinical response, survival, and safety outcomes in patients with progressive multifocal leukoencephalopathy (PML) treated with immune

Breaking the Wall: Can Intermittent Chemotherapy Overcome Primary Checkpoint Inhibitor Resistance in Metastatic Melanoma?
DermatologyCheckpoint Inhibitorsdrug resistance

Breaking the Wall: Can Intermittent Chemotherapy Overcome Primary Checkpoint Inhibitor Resistance in Metastatic Melanoma?

By MedXY|Mar 5, 2026

The multicentre phase II PROMIT trial demonstrates that intermittent dacarbazine can sensitize BRAF wildtype metastatic melanoma patients with primary ICI resistance to subsequent ICI rechallenge, yielding an 18% objective response rate and

Preexisting Antiviral Immunity and Allogeneic T-Cell Transfer: Redefining the Therapeutic Landscape of Progressive Multifocal Leukoencephalopathy
Infectious DiseasesCheckpoint Inhibitors

Preexisting Antiviral Immunity and Allogeneic T-Cell Transfer: Redefining the Therapeutic Landscape of Progressive Multifocal Leukoencephalopathy

By MedXY|Jan 26, 2026

Recent studies highlight the critical role of virus-specific T-cells in treating progressive multifocal leukoencephalopathy. Pre-existing T-cells predict superior responses to checkpoint inhibitors, while allogeneic T-cell transfer offers a

The Evolving Paradigm in High-Risk NMIBC: Critical Synthesis of Checkpoint Inhibitors and BCG Combination Therapy
newsBCGCheckpoint Inhibitors

The Evolving Paradigm in High-Risk NMIBC: Critical Synthesis of Checkpoint Inhibitors and BCG Combination Therapy

By MedXY|Jan 10, 2026

A comprehensive meta-analysis of the POTOMAC, CREST, and ALBAN trials reveals that adding PD-(L)1 inhibitors to BCG improves event-free survival in high-risk NMIBC. However, increased toxicity and agent-specific variations in efficacy sugge

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