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Cardiology

PDE9 Inhibition with CRD-740 Safely Elevates cGMP Levels in HFrEF: Results from the CARDINAL-HF Trial

The Phase 2 CARDINAL-HF trial demonstrates that CRD-740, a novel PDE9 inhibitor, significantly increases plasma and urinary cGMP in patients with heart failure and reduced ejection fraction. The treatment was well tolerated and effective ev

Dec 26, 2025Sign in to read
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Carboxypeptidase D (CPD) Mutations Cause Congenital Hearing Loss — and Point to an Actionable NO/cGMP Pathway

A JCI study links recessive CPD missense variants to congenital deafness, defines a pathogenic mechanism through impaired arginine–NO–cGMP signaling with ER stress and apoptosis, and shows rescue in models with arginine or sildenafil — offe

Nov 4, 2025

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