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Targeting SOX9-Driven SPEM Plasticity: A New Therapeutic Avenue to Prevent Gastric Cancer Progression
Gastroenterologycell plasticityGastric Cancer

Targeting SOX9-Driven SPEM Plasticity: A New Therapeutic Avenue to Prevent Gastric Cancer Progression

By MedXY|Jul 16, 2026

SOX9 is a pivotal regulator of SPEM cell plasticity driving gastric metaplasia and carcinogenesis. Therapeutically targeting SOX9 may prevent the progression of pre-cancerous lesions to gastric cancer by blocking metaplastic evolution.

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