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MedXY AI/MedXY News/Tag: CD8+ T cells
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Trogocytosis-Mediated CLDN18.2 Acquisition by CD8+ T Cells Impairs Anti-Tumor Immunity and Drives Pancreatic Cancer Progression
newspancreatic ductal adenocarcinomaCD8+ T cells

Trogocytosis-Mediated CLDN18.2 Acquisition by CD8+ T Cells Impairs Anti-Tumor Immunity and Drives Pancreatic Cancer Progression

By MedXY|Sep 17, 2026

This study reveals that CLDN18.2 acquired by CD8+ T cells through trogocytosis impairs their glucose metabolism and cytotoxic function, promoting pancreatic cancer progression and systemic immune senescence. Targeting this axis may enhance

Targeting the CXCL9/CXCL10-CXCR3+ CD8+ T Cell Axis: Unraveling Anti-PD-1 Antibody-Associated Cardiotoxicity in Pressure Overload Heart Failure
Cardiology
CD8+ T cells
heart failure

Targeting the CXCL9/CXCL10-CXCR3+ CD8+ T Cell Axis: Unraveling Anti-PD-1 Antibody-Associated Cardiotoxicity in Pressure Overload Heart Failure

By MedXY|Sep 6, 2026

Anti-PD-1 antibody exacerbates pressure overload-induced heart failure by promoting CXCR3+ CD8+ T cell infiltration, which impairs cardiomyocyte mitochondrial function via granzyme B and perforin. This study identifies a novel immunopathoge

Gut: Targeting Kupffer Cell Autophagy May Be A Novel Approach to Modulate CD8+ T Cell Activation in Primary Biliary Cholangitis
GastroenterologyCD8+ T cellsTherapeutic targets

Gut: Targeting Kupffer Cell Autophagy May Be A Novel Approach to Modulate CD8+ T Cell Activation in Primary Biliary Cholangitis

By MedXY|Aug 24, 2026

This article explores how autophagy in Kupffer cells influences CD8+ T cell activation and contributes to primary biliary cholangitis, highlighting potential therapeutic interventions targeting macrophage autophagy to alleviate liver inflam

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