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This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts mark
This study identifies immune biomarkers, including proliferative CD8+ T cells, CD68+ macrophages, and PD-1 expression, which differentiate high-risk oral tongue epithelial dysplasia and may improve patient risk stratification beyond convent
A Nature Immunology study reports that tumor cells shed antigen-bearing migrasomes during migration, boosting CD8 T-cell responses and reducing metastasis in mice; human data remain descriptive and no vaccine has been tested in people.
This study reveals that CLDN18.2 acquired by CD8+ T cells through trogocytosis impairs their glucose metabolism and cytotoxic function, promoting pancreatic cancer progression and systemic immune senescence. Targeting this axis may enhance
Anti-PD-1 antibody exacerbates pressure overload-induced heart failure by promoting CXCR3+ CD8+ T cell infiltration, which impairs cardiomyocyte mitochondrial function via granzyme B and perforin. This study identifies a novel immunopathoge
This article explores how autophagy in Kupffer cells influences CD8+ T cell activation and contributes to primary biliary cholangitis, highlighting potential therapeutic interventions targeting macrophage autophagy to alleviate liver inflam
