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Redefining the Renin-Aldosterone Axis: From Categorical Diagnosis to a Continuous Spectrum of Cardiorenal Risk

By MedXY|Apr 5, 2026

This article synthesizes evidence from a 2026 Danish nationwide cohort and supporting literature, illustrating that renin-independent aldosterone production represents a continuous risk gradient for kidney failure and MACE, even below tradi

Cardiologycardiorenal syndromeheart failure

Declining Kidney Function Often Precedes Heart Failure Hospitalization in HFrEF — Track eGFR Slopes, Not Just Thresholds

By MedXY|Nov 29, 2025

In HFrEF, eGFR often falls progressively for up to a year before heart-failure hospitalization or death. Monitoring eGFR trajectories provides earlier risk signals than single cut-offs and may identify patients for closer decongestion or th