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A phase 3 trial demonstrated that HTD1801 monotherapy significantly reduces HbA1c and improves cardiometabolic and inflammatory markers in patients with inadequately controlled type 2 diabetes, with sustained effects and a favorable safety
Long-term follow-up after two lifestyle trials found that reductions in visceral fat, more than overall weight loss, were linked to sustained cardiometabolic benefits and a lower risk of type 2 diabetes.
This randomized clinical trial demonstrates that combining high-intensity circuit training with targeted sleep health interventions significantly improves objective sleep quality and cardiometabolic markers in young women, outperforming eit
A randomized clinical trial demonstrates that combining high-intensity circuit training (HICT) with sleep health (SH) counseling significantly outperforms mono-interventions in improving sleep efficiency, reducing wakefulness, and enhancing
A randomized controlled trial investigates the 6-month effects of intermittent fasting on overweight adults, revealing significant improvements in lipid profiles and body composition despite neutral effects on blood pressure and glucose met
A post hoc analysis of the SURMOUNT-4 trial reveals that withdrawing tirzepatide leads to significant weight regain and a proportional reversal of improvements in blood pressure, glycemic control, and lipid profiles, reinforcing the necessi
A robust Mendelian randomization study demonstrates that the reduced risk of myocardial infarction associated with GLP-1 receptor agonists is primarily mediated by improvements in HbA1c, BMI, and lipid profiles, rather than direct cardiac e
A 7-day randomized study shows that both low- and high-protein fasting-mimicking diets improve cardiometabolic health and autophagy, with high-protein variants uniquely enhancing visceral fat reduction, lipid profiles, heart rate variabilit
A community-based intervention using ventilation hoods during cooking reduced 24-hour PM2.5 exposure by nearly 30% and improved cardiometabolic and pulmonary health markers in rural Chinese villages reliant on wood fuel.
Recent studies link irregular sleep to higher risks of type 2 diabetes, cardiometabolic diseases, all-cause mortality, and depression. Consistent sleep timing may offer crucial protection against these adverse outcomes.
