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MedXY AI/MedXY News/Tag: Cardiac Remodeling
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Cardiac Remodeling

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Proteomic and Metabolomic Insights into Cardiac Remodeling in Breast Cancer Patients Undergoing Cardiotoxic Therapy
CardiologyCardiotoxicitymetabolomics

Proteomic and Metabolomic Insights into Cardiac Remodeling in Breast Cancer Patients Undergoing Cardiotoxic Therapy

By MedXY|Sep 19, 2026

This study identifies novel proteomic and metabolomic biomarkers linked to cardiac dysfunction and remodeling in breast cancer patients treated with cardiotoxic therapies, revealing potential pathways for early detection and intervention.

Targeting the CCND1-PDK4 Axis to Promote Reparative Macrophage Phenotype and Mitigate Post-Myocardial Infarction Cardiac Remodeling
CardiologyMetabolic Reprogramming
マクロファージ極性化

Targeting the CCND1-PDK4 Axis to Promote Reparative Macrophage Phenotype and Mitigate Post-Myocardial Infarction Cardiac Remodeling

By MedXY|Sep 19, 2026

This article discusses the role of cyclin D1 (CCND1) in promoting reparative macrophage transition post-myocardial infarction, highlighting its therapeutic potential in reducing adverse cardiac remodeling through metabolic reprogramming.

Illuminating the Night: How Nighttime Light Exposure Impacts Cardiac Structure, Function, and Cardiovascular Risk
Cardiologysleep durationcardiovascular risk

Illuminating the Night: How Nighttime Light Exposure Impacts Cardiac Structure, Function, and Cardiovascular Risk

By MedXY|Sep 15, 2026

Nighttime light exposure over 3 lux is linked to adverse cardiac remodeling, subclinical functional decline, and increased cardiovascular events, partly mediated by shorter sleep duration, underscoring the importance of dark nights and slee

Oral Relaxin Receptor Agonist AZD5462 Shows Promise in Chronic Heart Failure: Insights from the LUMINARA Trial
Cardiologysystemic vascular resistanceAZD5462

Oral Relaxin Receptor Agonist AZD5462 Shows Promise in Chronic Heart Failure: Insights from the LUMINARA Trial

By MedXY|Sep 3, 2026

The LUMINARA trial evaluates AZD5462, an oral relaxin receptor agonist, demonstrating safety and promising effects on cardiac remodeling and vascular resistance in chronic heart failure, warranting further large-scale investigation.

Low Ventricular Chamber Stiffness as a Marker of High-Risk Eccentric Remodeling in Fontan Circulation: Insights from the FORCE Registry
CardiologyCardiac RemodelingFontan

Low Ventricular Chamber Stiffness as a Marker of High-Risk Eccentric Remodeling in Fontan Circulation: Insights from the FORCE Registry

By MedXY|Aug 29, 2026

Lower ventricular chamber stiffness predicts adverse outcomes in Fontan patients, revealing a high-compliance, eccentric remodeling phenotype distinct from traditional stiffening hypotheses.

RUNX1-Driven Endothelial-to-Mesenchymal Transition: A Novel Mechanistic Link and Therapeutic Target in LMNA Cardiomyopathy
CardiologyLMNA cardiomyopathyRUNX1

RUNX1-Driven Endothelial-to-Mesenchymal Transition: A Novel Mechanistic Link and Therapeutic Target in LMNA Cardiomyopathy

By MedXY|Aug 21, 2026

This study identifies RUNX1-mediated endothelial-to-mesenchymal transition as a key driver of myocardial fibrosis and remodeling in LMNA cardiomyopathy, highlighting potential therapeutic avenues targeting endothelial RUNX1 signaling.

Unveiling the Natural History of Asymptomatic Mild Hypertrophic Cardiomyopathy: Insights from the SHaRe Registry
CardiologyasymptomaticCardiac Remodeling

Unveiling the Natural History of Asymptomatic Mild Hypertrophic Cardiomyopathy: Insights from the SHaRe Registry

By MedXY|Jul 9, 2026

This study reveals that 21% of asymptomatic patients with mild HCM develop major adverse cardiovascular events over 7 years, highlighting key predictors such as age, symptom progression, and cardiac remodeling markers that inform management

Environmental Cardiotoxicity: PM2.5 and Ozone Exposure Double the Risk of Cardiac Dysfunction in Breast Cancer Patients
Cardiologyair pollutionbreast cancer

Environmental Cardiotoxicity: PM2.5 and Ozone Exposure Double the Risk of Cardiac Dysfunction in Breast Cancer Patients

By MedXY|Feb 9, 2026

A prospective study reveals that PM2.5 and ozone exposure significantly exacerbate cardiac dysfunction and adverse remodeling in breast cancer patients receiving anthracyclines or trastuzumab, doubling the risk of clinical LVEF decline.

Mavacamten Redefines Long-Term Outcomes in Obstructive Hypertrophic Cardiomyopathy: 128-Week Results From the VALOR-HCM Trial
CardiologyCardiac RemodelingHypertrophic Cardiomyopathy

Mavacamten Redefines Long-Term Outcomes in Obstructive Hypertrophic Cardiomyopathy: 128-Week Results From the VALOR-HCM Trial

By MedXY|Jan 17, 2026

The 128-week follow-up of the VALOR-HCM trial demonstrates that mavacamten provides sustained relief from LVOT obstruction, promotes favorable cardiac remodeling, and significantly reduces the need for invasive septal reduction therapy in p

Genetic Susceptibility and Elite Rowing: The Dual Drivers of Atrial Fibrillation Risk in Former Athletes
Cardiologyatrial fibrillationCardiac Remodeling

Genetic Susceptibility and Elite Rowing: The Dual Drivers of Atrial Fibrillation Risk in Former Athletes

By MedXY|Jan 6, 2026

A landmark study reveals that former world-class rowers face a seven-fold higher risk of atrial fibrillation compared to the general population, driven by a combination of intensive cardiac remodeling and a strong polygenic predisposition.

Higher-Quality Carbohydrates and Fibre-Rich Foods Associate with Better Left Ventricular Structure and Function: Insights from CARDIA
CardiologyCardiac Remodelingleft ventricular function

Higher-Quality Carbohydrates and Fibre-Rich Foods Associate with Better Left Ventricular Structure and Function: Insights from CARDIA

By MedXY|Nov 28, 2025

In the CARDIA cohort, higher carbohydrate quality (lower carbohydrate:fibre ratio) and greater intake of fibre-rich foods were associated with more favorable left ventricular structure and function measured 25–30 years after baseline diet a

Dapagliflozin and Cardiac Remodeling in Chronic Kidney Disease: New Evidence for Cardioprotection
CardiologyCardiac Remodelingchronic kidney disease

Dapagliflozin and Cardiac Remodeling in Chronic Kidney Disease: New Evidence for Cardioprotection

By MedXY|Oct 30, 2025

Dapagliflozin reduces left ventricular mass index in chronic kidney disease patients, revealing a key mechanism for cardioprotective effects of SGLT2 inhibitors and highlighting early treatment benefits.

Untangling Adiposity and Insulin Resistance in HFpEF: Clarifying Their Distinct Impact on Cardiac Function
CardiologyCardiac RemodelingHFpEF

Untangling Adiposity and Insulin Resistance in HFpEF: Clarifying Their Distinct Impact on Cardiac Function

By MedXY|Oct 4, 2025

This study reveals that excess adiposity, rather than insulin resistance or diabetes, predominantly drives left heart abnormalities and elevated pulmonary pressures in HFpEF, highlighting the need for targeted cardiometabolic therapies beyo

Aficamten in Obstructive Hypertrophic Cardiomyopathy: Durable 48-Week Benefits and Insights on Combination Therapy
CardiologyAficamtenCardiac Remodeling

Aficamten in Obstructive Hypertrophic Cardiomyopathy: Durable 48-Week Benefits and Insights on Combination Therapy

By MedXY|Oct 3, 2025

Aficamten shows sustained obstruction relief, symptom improvement, and favorable cardiac remodeling over 48 weeks in obstructive hypertrophic cardiomyopathy, with safe discontinuation of disopyramide possible.

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