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Pre-Diagnostic Low-Normal Immunoglobulin Levels Identify Early Clonal B-cell Dysregulation and CLL Susceptibility: Insights from a Large Retrospective Cohort
Hematology-Oncologycancer susceptibilityimmunoglobulin levels

Pre-Diagnostic Low-Normal Immunoglobulin Levels Identify Early Clonal B-cell Dysregulation and CLL Susceptibility: Insights from a Large Retrospective Cohort

By MedXY|Aug 20, 2026

Low-normal immunoglobulin levels, particularly IgA, measured up to a decade before diagnosis, are predictive of chronic lymphocytic leukemia risk through dual mechanisms involving monoclonal B-cell lymphocytosis and constitutional susceptib

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