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Caloric Restriction

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Diabetes & Endocrinology

Weight Regain Can Reverse the Metabolic Benefits of Caloric Restriction: Insights From CALERIE-2

CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.

May 13, 2026
Clinical Updates

Decoding Metabolic Adaptation: Caloric Restriction’s Impact on Organ Size in the CALERIE 2 Trial

This study explores how caloric restriction influences organ size and metabolic adaptation, using MRI data from the CALERIE 2 trial, revealing nuanced changes in energy expenditure linked to organ-specific tissue loss.

Sep 16, 2025

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