Cardiologycalcium handlingcardiomyocyte
SREBP1 Activation of NHE3 Weakens Heart Contraction and Worsens Heart Failure
By MedXY|May 23, 2026
Researchers found that SREBP1 directly activates NHE3 in failing hearts, causing sodium and calcium overload, weaker cardiac contraction, and worse heart failure. The findings reveal a new mechanism in HFrEF and suggest a potential therapeu