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Incidental DWI-Positive Lesions as Emerging Biomarkers in Cerebral Small Vessel Disease: Insights from CAA and CADASIL Cohorts

Incidental DWI-positive lesions are prevalent in cerebral amyloid angiopathy and CADASIL, showing disease-specific distributions and associations with neurodegeneration and MRI biomarkers. These findings underscore their potential role as m

Jun 28, 2026
Clinical Updates

Distinct Small Vessel Disease Phenotype Linked to Monoallelic NOTCH3 Loss-of-Function Variants: Differentiation from CADASIL and Clinical Implications

Monoallelic NOTCH3 loss-of-function variants cause a subclinical small vessel disease distinct from CADASIL, with white matter changes but lower stroke risk; cardiovascular risk factors and aging exacerbate the phenotype.

Sep 4, 2025Sign in to read

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