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Procainamide Challenge for Brugada Syndrome: Establishing Diagnostic Safety and the Reassuring Prognosis of Induced Patterns
CardiologyBrugada syndromeElectrophysiology

Procainamide Challenge for Brugada Syndrome: Establishing Diagnostic Safety and the Reassuring Prognosis of Induced Patterns

By MedXY|Dec 25, 2025

A large-scale registry study confirms that procainamide infusion is exceptionally safe for Brugada syndrome diagnosis, with high sensitivity and specificity. Crucially, asymptomatic patients with a procainamide-induced type 1 pattern demons

High-throughput automated patch clamp transforms SCN5A variant interpretation and penetrance estimates in Brugada syndrome
CardiologyBrugada syndrome

High-throughput automated patch clamp transforms SCN5A variant interpretation and penetrance estimates in Brugada syndrome

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By MedXY|Nov 29, 2025

Automated patch-clamp functional data from two multisite studies reclassify many SCN5A VUS, link loss-of-function severity to penetrance, and provide ClinGen-calibrated, clinical-grade evidence to improve diagnosis and family management in

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