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This feasibility RCT demonstrates that the HOPE4ABI digital intervention is acceptable and beneficial for improving mental, sexual wellbeing, and quality of life in stroke and brain injury survivors, warranting a definitive efficacy trial.
This study identifies systemic pathological pathways that mediate blood-brain barrier injury in sickle cell disease, linking BBB disruption to brain hypoxia and microstructural injury, highlighting new therapeutic targets to preserve neurol
This exploratory longitudinal study reveals that alongside decreased glucose metabolism, elevated brainstem methionine uptake correlates with consciousness improvement in brain-injured patients, highlighting novel metabolic biomarkers for p
This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.
A prospective study demonstrates that rising levels of plasma GFAP and NfL precede neuroimaging-confirmed brain injury in children on ECMO. These biomarkers are also strongly associated with mortality and long-term functional impairment, of
