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MedXY AI/MedXY News/Tag: blood–brain barrier
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Clinical Implications of Hyperintense Reperfusion Marker and Ocular Gadolinium Leakage Post-Thrombectomy: Insights from the ETIS Registry
Clinical Updatesmechanical thrombectomyblood–brain barrier

Clinical Implications of Hyperintense Reperfusion Marker and Ocular Gadolinium Leakage Post-Thrombectomy: Insights from the ETIS Registry

By MedXY|Aug 25, 2026

This review elucidates the prognostic significance of HARM and GLOS as imaging biomarkers after mechanical thrombectomy, highlighting their associations with early neurological outcomes and infarct progression.

DKK2 Inhibition: A Novel Neurovascular Strategy to Salvage the Ischaemic Penumbra and Protect the Blood-Brain Barrier
Cardiologyblood–brain barrier
Ischaemic Stroke

DKK2 Inhibition: A Novel Neurovascular Strategy to Salvage the Ischaemic Penumbra and Protect the Blood-Brain Barrier

By MedXY|Jan 2, 2026

New research published in the European Heart Journal identifies Dickkopf-related protein 2 (DKK2) as a primary driver of neurovascular injury post-stroke. By suppressing Wnt signalling, DKK2 exacerbates neuronal death and blood-brain barrie

Breakthrough in Hunter Syndrome: Brain-Penetrant Enzyme Therapy Stabilizes Cognitive Function and Clears Lysosomal Substrates
Neurologyblood–brain barrierMucopolysaccharidosis II

Breakthrough in Hunter Syndrome: Brain-Penetrant Enzyme Therapy Stabilizes Cognitive Function and Clears Lysosomal Substrates

By MedXY|Dec 31, 2025

A Phase 1-2 study of tividenofusp alfa reveals a 91% reduction in CSF heparan sulfate and stabilized adaptive behavior in children with MPS II, overcoming the blood-brain barrier via transferrin receptor-mediated transport.

Microbubble‑Enhanced Focused Ultrasound with Temozolomide Shows Feasibility and Promising Survival in High‑Grade Glioma — Phase 1/2 Multicentre Results
Neurologyblood–brain barrierfocused ultrasound

Microbubble‑Enhanced Focused Ultrasound with Temozolomide Shows Feasibility and Promising Survival in High‑Grade Glioma — Phase 1/2 Multicentre Results

By MedXY|Nov 29, 2025

A multicentre phase 1/2 trial reports that MRI‑guided microbubble‑enhanced transcranial focused ultrasound (MB‑FUS) can safely open the blood–brain barrier and be combined with standard adjuvant temozolomide in high‑grade glioma, with media

Early-Life Gut Microbiome Maturity: A Key Regulator of Blood-Brain Barrier Integrity and Cognitive Development
Clinical Updatesblood–brain barriercognitive development

Early-Life Gut Microbiome Maturity: A Key Regulator of Blood-Brain Barrier Integrity and Cognitive Development

By MedXY|Sep 30, 2025

This study demonstrates that the maturity of the early-life gut microbiome influences blood-brain barrier integrity and cognitive functions, highlighting a novel therapeutic target for neurodevelopmental disorders.

Harnessing Exosomes in Neurodegenerative Diseases: Therapeutic Promise and Modification Techniques
Neurologyblood–brain barrierneurodegenerative diseases

Harnessing Exosomes in Neurodegenerative Diseases: Therapeutic Promise and Modification Techniques

By MedXY|Oct 4, 2025

Exosomes, nanoscale vesicles capable of crossing the blood–brain barrier, hold significant potential as targeted therapeutic agents and diagnostic markers in neurodegenerative diseases. Advances in genetic, chemical, and nanomaterial modifi

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