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Rapid and excessive expansion of ciltacabtagene autoleucel (cilta-cel) CAR T-cells associates with delayed neurotoxicity in relapsed/refractory multiple myeloma, with absolute lymphocyte count serving as a practical biomarker to guide early
This study identifies serum and gene expression signatures predicting successful canakinumab tapering in systemic juvenile idiopathic arthritis, offering precision medicine strategies to reduce flares.
A large European cohort study identifies six circulating metabolites significantly associated with future stroke risk, highlighting their potential in improving early stroke risk prediction beyond classic risk factors.
This pooled analysis of seven multi-ethnic cohorts demonstrates the combined prognostic value of plasma phosphorylated tau 217 concentrations and APOE-ε4 genotype for predicting risk and timing of cognitive impairment, emphasizing biomarker
This study reveals distinct alterations in the type I interferon pathway expression and signaling linked to mutated p53 subtypes in endometrial cancer, highlighting differing immune microenvironments that impact prognosis and therapeutic co
Circulating extracellular vesicles carrying PD-1, PD-L1, and CTLA-4 can non-invasively predict responses and early resistance to immune checkpoint inhibitors in advanced hepatocellular carcinoma, improving patient stratification and managem
A metabolomic clock based on plasma metabolites accurately estimated chronological age (r=0.92) and was associated with mortality, frailty, and cognitive impairment across two European cohorts.
Hyperreflective abnormalities in middle retinal layers detected by en face OCT improve diagnostic discrimination of referable diabetic retinopathy, offering a promising adjunct biomarker beyond clinical parameters.
Fecal calprotectin offers a non-invasive, dynamic biomarker to predict, diagnose, and monitor GI-GVHD post-allo-HSCT, correlating with endoscopic severity and treatment response, but requires integrated clinical interpretation due to limite
Thyroid hormone signaling may influence ADPKD progression, with preclinical cyst suppression and patient biomarker associations suggesting prognostic and therapeutic potential.
Plasma profiling identified a three-miRNA panel associated with beta cell rate sensitivity across glucose tolerance stages, suggesting a minimally invasive approach to detect early insulin secretory decline.
This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.
P85-Ab, an anti-EBV BNLF2b antibody test, showed excellent accuracy for suspected nasopharyngeal carcinoma and outperformed older EBV markers in most outpatient settings.
GI biopsies reveal misfolded proteins years before neurological symptoms appear, offering a new biomarker for early neurodegenerative disease prediction and intervention.
A five-RNA extracellular vesicle signature showed strong diagnostic performance for chronic pancreatitis and may also reflect acinar-to-ductal metaplasia and disease-related metabolic features.
A large retrospective cohort study of 143,517 patients reveals that non-eosinophilic acute exacerbations of COPD carry a significantly higher one-year risk of major adverse cardiovascular events compared with eosinophilic exacerbations, sug
A prospective multicenter study validates the high accuracy of a saliva microRNA signature for noninvasive endometriosis diagnosis, demonstrating superior performance to imaging modalities and promising clinical utility.
Comprehensive proteogenomic profiling in resected extrahepatic cholangiocarcinoma reveals predictive biomarkers for tailoring adjuvant chemotherapy, offering a precision medicine approach to improve patient outcomes.
RIPK3-associated necroptosis critically drives organ failure and mortality in acute decompensation and ACLF, with its plasma levels robustly predicting outcomes and improving prognostic models to guide personalized therapies.
New research identifies a protein signature in blood that detects ALS years before symptoms, challenging previous perceptions and offering hope for early diagnosis and intervention.
