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Cardiologybile acidsendothelial dysfunction

Taurochenodeoxycholic Acid: A Novel Metabolic Sentinel Reversing Obesity-Induced Endothelial Dysfunction via the FXR-PHB1-ATF4 Axis

By MedXY|Mar 9, 2026

This study identifies TCDCA as a key metabolite that restores endothelial function in obesity. By activating the endothelial FXR-PHB1-ATF4 pathway, TCDCA enhances serine metabolism, offering a promising therapeutic strategy to mitigate card

Clinical UpdatesBarrett's esophagusbile acids

Decoding the Role of Reflux Secondary Bile Acids in Barrett’s Esophagus: Microbiome and Transcriptome Insights

By MedXY|Oct 9, 2025

This study reveals that elevated reflux secondary bile acids in Barrett’s esophagus influence the esophageal microbiome and gene expression, highlighting potential mechanisms underpinning progression to esophageal adenocarcinoma.

Clinical Updatesbile acidspruritus

Unraveling the Drivers of Pruritus Severity in Intrahepatic Cholestasis of Pregnancy: Insights from a Longitudinal Cohort Study

By MedXY|Sep 30, 2025

Peak bile acid levels and higher maternal BMI independently predict pruritus worsening in intrahepatic cholestasis of pregnancy, emphasizing the need for tailored monitoring and management as gestation advances.