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The oxidized phospholipid PGPC inhibits angiogenesis in ischemic heart disease by impairing endothelial autophagic flux through NPC1-induced acetylation and ubiquitination of syntaxin 17, unveiling new potential therapeutic targets for coro
This article explores how autophagy in Kupffer cells influences CD8+ T cell activation and contributes to primary biliary cholangitis, highlighting potential therapeutic interventions targeting macrophage autophagy to alleviate liver inflam
New research identifies transcription factor ATF3 as a key regulator of vascular smooth muscle cell aging and reveals low-dose trazosin, a commonly used antihypertensive, as a potential therapy to delay vascular aging and atherosclerosis pr
Linarin shows promise in mitigating NAFLD by enhancing autophagy via PI3K/Akt/mTOR inhibition, reducing inflammation, and restoring gut microbiota balance, alongside activating the PDE4D/cAMP/PKA/CREB pathway to improve hepatic lipid metabo
A 7-day randomized study shows that both low- and high-protein fasting-mimicking diets improve cardiometabolic health and autophagy, with high-protein variants uniquely enhancing visceral fat reduction, lipid profiles, heart rate variabilit
