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Vagal Nerve Stimulation in HFrEF Was Safe but Did Not Improve the Primary Composite Outcome in the ANTHEM-HFrEF Trial
CardiologyANTHEM-HFrEFautonomic modulation

Vagal Nerve Stimulation in HFrEF Was Safe but Did Not Improve the Primary Composite Outcome in the ANTHEM-HFrEF Trial

By MedXY|May 23, 2026

In ANTHEM-HFrEF, vagal nerve stimulation in symptomatic HFrEF was feasible and safe, but the underpowered trial did not meet its primary efficacy endpoint after premature sponsor-driven termination.

Enhancing Exercise Capacity Through Non-Invasive Vagus Nerve Stimulation: Evidence from a Randomized Controlled Trial
Neurologyautonomic modulation
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cardiorespiratory fitness

Enhancing Exercise Capacity Through Non-Invasive Vagus Nerve Stimulation: Evidence from a Randomized Controlled Trial

By MedXY|Oct 3, 2025

A randomized trial demonstrates that non-invasive transcutaneous vagus nerve stimulation improves peak oxygen uptake and exercise performance in healthy volunteers, highlighting its potential as a safe and scalable method to boost cardiores

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