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Rademikibart and Eosinophil Counts in Moderate-to-Severe Asthma: Insights from a Phase 2b Randomized Trial
Allergy & ImmunologyEosinophilsRademikibart

Rademikibart and Eosinophil Counts in Moderate-to-Severe Asthma: Insights from a Phase 2b Randomized Trial

By MedXY|Sep 18, 2026

This article reviews exploratory analyses from a phase 2b trial examining eosinophil count changes in adults with uncontrolled moderate-to-severe asthma treated with the IL-4Rα inhibitor rademikibart, indicating a low risk of treatment-emer

From Mild-to-Moderate to Severe Asthma: Risk Factors and Patient Profiles from the NORDSTAR Cohort and Advances in Severe Asthma Management
Clinical Updatesasthma progression
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From Mild-to-Moderate to Severe Asthma: Risk Factors and Patient Profiles from the NORDSTAR Cohort and Advances in Severe Asthma Management

By MedXY|Sep 17, 2026

This review summarizes the progression risk from mild-to-moderate to severe asthma based on the NORDSTAR cohort and integrates emerging evidence on biologic therapies that improve severe asthma outcomes across diverse patient profiles.

Empowering Climate-Conscious Inhaler Prescribing: A Patient-Physician Conversation Aid
Family Medicine & Nutritionasthmaclimate-conscious prescribing

Empowering Climate-Conscious Inhaler Prescribing: A Patient-Physician Conversation Aid

By MedXY|Jun 30, 2026

A novel conversation aid was developed and refined iteratively with patients and physicians to support shared decision-making for low carbon footprint inhaler prescribing in asthma and COPD, balancing environmental impact with safety and pa

Dietary Patterns and Asthma Endotypes in Puerto Rican Youth
newsasthmadiet

Dietary Patterns and Asthma Endotypes in Puerto Rican Youth

By MedXY|Jun 4, 2026

In Puerto Rican youth, an unhealthy diet was linked to higher odds of T17-high asthma, suggesting diet may influence asthma through immune pathways beyond allergy-related inflammation.

Redefining Reliever Therapy: Budesonide-Formoterol Outperforms SABA in Controlling Airway Inflammation Among Patients on Maintenance Corticosteroids
Allergy & ImmunologyasthmaFeNO

Redefining Reliever Therapy: Budesonide-Formoterol Outperforms SABA in Controlling Airway Inflammation Among Patients on Maintenance Corticosteroids

By MedXY|Feb 19, 2026

The INFORM ASTHMA trial demonstrates that budesonide-formoterol as a reliever significantly reduces Type 2 airway inflammation (FeNO) compared to terbutaline in adults already using maintenance inhaled corticosteroids, establishing a new ev

Dupilumab Surpasses Omalizumab for Type‑2 Respiratory Disease: Converging Evidence from a Head‑to‑Head RCT, Real‑World US Data, and a Target‑Trial Emulation
Allergy & Immunologyasthmadupilumab

Dupilumab Surpasses Omalizumab for Type‑2 Respiratory Disease: Converging Evidence from a Head‑to‑Head RCT, Real‑World US Data, and a Target‑Trial Emulation

By MedXY|Dec 1, 2025

Three complementary studies—EVEREST (head‑to‑head RCT), the US ADVANTAGE real‑world study, and a target‑trial emulation—consistently show greater reductions in nasal polyp burden, smell loss, asthma exacerbations, and systemic steroid use w

Unveiling Diverse Inflammatory Pathways in Residual Pediatric Asthma Exacerbations Under Mepolizumab Therapy
Allergy & Immunologyasthmainflammation

Unveiling Diverse Inflammatory Pathways in Residual Pediatric Asthma Exacerbations Under Mepolizumab Therapy

By MedXY|Oct 27, 2025

This study reveals multiple distinct molecular mechanisms, including epithelial and macrophage pathways, that contribute to residual asthma exacerbations in children treated with mepolizumab, highlighting the complexity of airway inflammati

Budesonide-Formoterol Reliever Therapy Demonstrates Superiority over Salbutamol in Children with Mild Asthma: Insights from the CARE Trial
newsasthma

Budesonide-Formoterol Reliever Therapy Demonstrates Superiority over Salbutamol in Children with Mild Asthma: Insights from the CARE Trial

By MedXY|Oct 10, 2025

The CARE trial shows that budesonide-formoterol reliever monotherapy significantly reduces asthma attack rates compared to salbutamol in children aged 5-15 years with mild asthma, with comparable safety over 52 weeks.

Persistent Use of Green Cleaning Products Linked to Increased Asthma Risk: Implications for Clinical Practice
Allergy & Immunologyasthmarespiratory health

Persistent Use of Green Cleaning Products Linked to Increased Asthma Risk: Implications for Clinical Practice

By MedXY|Oct 9, 2025

Longitudinal data from the French NutriNet-Santé cohort reveal that persistent and increased use of green cleaning products is associated with a modest but significant rise in asthma symptoms, underscoring the need for cautious use and pati

Asthma and the Risk of Degenerative Valvular Heart Disease: Insights from a Large Prospective Cohort Study
Allergy & Immunologyasthmacardiovascular risk

Asthma and the Risk of Degenerative Valvular Heart Disease: Insights from a Large Prospective Cohort Study

By MedXY|Oct 4, 2025

This study demonstrates that asthma modestly increases the risk of degenerative valvular heart diseases, highlighting the need for cardiovascular vigilance in asthmatic individuals.

Empowering Parents: Acceptance and Commitment Therapy for Children With Asthma and ADHD
Allergy & ImmunologyAcceptance and Commitment TherapyADHD

Empowering Parents: Acceptance and Commitment Therapy for Children With Asthma and ADHD

By MedXY|Oct 1, 2025

A randomized clinical trial demonstrates that an Acceptance and Commitment Therapy-based parenting program reduces health care use, improves asthma control, and alleviates ADHD symptoms in children with both conditions.

As-Needed Albuterol–Budesonide Therapy in Mild Asthma: Clinical Impact and Comparative Evidence
newsasthmabudesonide

As-Needed Albuterol–Budesonide Therapy in Mild Asthma: Clinical Impact and Comparative Evidence

By MedXY|Sep 30, 2025

As-needed albuterol–budesonide significantly reduces severe exacerbations in mild asthma compared to albuterol alone, with comparable safety. Two pivotal trials confirm efficacy across lung function and exacerbation outcomes.

Cockroach Immunotherapy Modulates Key T-Cell Responses Regardless of Allergen Extract Abundance
Allergy & Immunologyasthmaimmunotherapy

Cockroach Immunotherapy Modulates Key T-Cell Responses Regardless of Allergen Extract Abundance

By MedXY|Sep 30, 2025

A randomized trial finds that subcutaneous cockroach immunotherapy effectively downregulates dominant T-cell responses in pediatric asthma, independent of allergen abundance in the therapeutic extract.

Digital Self-Management Tools Enhance Asthma Control
Allergy & Immunologyasthmadigital health

Digital Self-Management Tools Enhance Asthma Control

By MedXY|Sep 30, 2025

A randomized trial shows that a smartphone-based asthma self-management program improves symptom control in adults, though its effectiveness is attenuated in African American participants.

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