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This review synthesizes findings from the CLEAN-IT trial and historical data to evaluate the impact of chlorhexidine bathing on nosocomial infections, MDR pathogens, and reserve antibiotic consumption in critically ill patients.
A randomized multimethod study reveals that while AI clinical decision support systems for antibiotic switching are well-received, their primary influence is reinforcing conservative prescribing. The study underscores that usability and cli
A large-scale multinational study reveals that meropenem and piperacillin dosing during renal replacement therapy must be tailored to RRT intensity and urine output, with extended infusions significantly improving therapeutic target attainm
A global meta-analysis reveals that over 40% of primary care prescriptions contain antibiotics, with more than half being inappropriate, highlighting urgent needs for improved antimicrobial stewardship worldwide.
A Danish multicentre trial found individualised, shorter antibiotic regimens for febrile pediatric UTIs reduce overall antibiotic exposure and adverse events, but with a modestly higher recurrence risk compared to standard 10-day treatment.