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A 2026 expert consensus recommends shorter, individualized antibiotic courses for most severe infections in critically ill patients, with clear exceptions and guidance on biomarkers, source control, and stewardship.
This review synthesizes findings from the CLEAN-IT trial and historical data to evaluate the impact of chlorhexidine bathing on nosocomial infections, MDR pathogens, and reserve antibiotic consumption in critically ill patients.
A randomized multimethod study reveals that while AI clinical decision support systems for antibiotic switching are well-received, their primary influence is reinforcing conservative prescribing. The study underscores that usability and cli
A large-scale multinational study reveals that meropenem and piperacillin dosing during renal replacement therapy must be tailored to RRT intensity and urine output, with extended infusions significantly improving therapeutic target attainm
A global meta-analysis reveals that over 40% of primary care prescriptions contain antibiotics, with more than half being inappropriate, highlighting urgent needs for improved antimicrobial stewardship worldwide.
A Danish multicentre trial found individualised, shorter antibiotic regimens for febrile pediatric UTIs reduce overall antibiotic exposure and adverse events, but with a modestly higher recurrence risk compared to standard 10-day treatment.
