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Consensus Molecular Subtype 4 (CMS4) Identifies RAS Wild-Type mCRC Patients Who May Benefit Preferentially from Anti‑EGFR Therapy

An individual patient data meta-analysis of 790 RAS wild-type metastatic colorectal cancer patients suggests CMS4 tumors derive meaningful progression-free and overall survival benefit from anti‑EGFR versus anti‑VEGF antibodies, warranting

Dec 8, 2025
Clinical Updates

Prognostic Role of HER2 Amplification and Mutations in Metastatic Colorectal Cancer: Insights from Eight Randomized Trials

HER2 amplification/mutation in RAS/BRAF wild-type metastatic colorectal cancer is a negative prognostic factor but does not predict differential benefit from bevacizumab or anti-EGFR therapies, based on analysis of 1,604 patients across eig

Sep 10, 2025Sign in to read

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