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Breaking the Brake: How Annexin A2 Inhibition Restores Mitophagy and Salvages the Infarcted Heart
CardiologyAnnexin A2mitophagy

Breaking the Brake: How Annexin A2 Inhibition Restores Mitophagy and Salvages the Infarcted Heart

By MedXY|Mar 25, 2026

This study identifies Annexin A2 as a critical negative regulator of PHB2-mediated mitophagy in myocardial infarction. By promoting PHB2 degradation via the TRIM29 ligase, ANXA2 exacerbates cardiac injury. Inhibiting ANXA2 restores mitochon

Unlocking Mitochondrial Resilience: How Annexin A2 Inhibition Protects the Infarcted Heart
CardiologyAnnexin A2mitophagy

Unlocking Mitochondrial Resilience: How Annexin A2 Inhibition Protects the Infarcted Heart

By MedXY|Mar 21, 2026

Researchers identify Annexin A2 as a key inhibitor of mitophagy in the heart. By blocking the mitophagy receptor PHB2, ANXA2 exacerbates cardiac injury after myocardial infarction. This study demonstrates that targeting ANXA2 restores mitoc

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