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Systemic Inflammation as a Modulator of Anhedonia in Major Depressive Disorder: Insights from an LPS Challenge Trial

This RCT reveals that adults with major depressive disorder and elevated systemic inflammation exhibit heightened anhedonic responses to an inflammatory challenge, highlighting inflammation’s role in depression symptomatology.

Oct 31, 2025Sign in to read
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Azetukalner: A Novel KV7 Potassium Channel Opener Shows Promise in Treating Major Depressive Disorder

Azetukalner, a KV7 potassium channel opener, demonstrated clinically meaningful antidepressant effects and significant improvement in anhedonia in adults with major depressive disorder in a 6-week randomized trial, supporting further develo

Oct 21, 2025

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