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This review synthesizes evidence on racial and ethnic differences in plasma phosphorylated tau 217 (%p-tau217) in preclinical Alzheimer disease, highlighting implications for diagnostic screening and biomarker validity across diverse popula
Plasma pTau217 levels measured by Lumipulse G assays strongly correlate with postmortem temporal cortex pTau217 pathology, supporting plasma pTau217 as a reliable biomarker for brain tau pathology in Alzheimer disease.
This review synthesizes recent evidence linking menopausal hormone therapy (MHT), particularly estrogen-only regimens, with decreased Alzheimer disease neuropathology and clinical dementia risk, highlighting biomarker correlations, clinical
Among older adults with incident dementia, Alzheimer disease and LATE-NC pathologies were independently linked to higher odds of receiving a timely diagnosis, while vascular pathology and Lewy bodies showed no significant association.
This study reveals significant income and productivity losses up to 15 years before diagnosis in early-onset dementia, varying across subtypes, underscoring the urgent need for earlier detection and support.
SS-OCTA identified retinal and choriocapillaris microvascular changes associated with cognitive status in Alzheimer disease, including thinner GCC in dementia and a biphasic CCFD pattern, suggesting a promising noninvasive biomarker platfor
Plasma %p-tau217 plus eMTBR-tau243 showed strong agreement with amyloid/tau PET staging, tracked clinical severity, and aligned with neuropathology, supporting a scalable blood-based approach to Alzheimer disease biological staging.
In the HUNT Study, higher midlife waist-to-height ratio and BMI predicted higher late-life plasma p-tau217 and biomarker-verified Alzheimer dementia, whereas higher adiposity in late life was associated with lower biomarker levels and lower
A randomized clinical trial found that dementia screening for family members of older adults did not improve quality of life or caregiver preparedness, nor did it increase depression or anxiety.
A Brazilian autopsy study of 2,268 individuals reveals that female sex, APOE ε4 status, and African ancestry jointly influence amyloid pathology. Women showed 65% higher adjusted odds of neuritic plaques, and protective effects against amyl
This cross-sectional study of 2,268 autopsies reveals that female sex, APOEε4 status, and African ancestry independently and jointly influence neuritic plaque burden, suggesting that current Alzheimer’s biomarker thresholds may need refinem
Research indicates that circulating levels of the longevity protein klotho can moderate the relationship between cerebral atrophy and cognitive performance in older adults, suggesting a biological mechanism for cognitive resilience even in
This review synthesizes recent high-impact evidence on plasma p-tau217, demonstrating its superior utility in identifying amyloid pathology, predicting cognitive decline, and optimizing recruitment for primary prevention trials in cognitive
A randomized clinical trial demonstrates that home-based gamma transcranial alternating current stimulation (tACS) over the precuneus safely improves cognitive outcomes and activities of daily living in patients with prodromal and mild Alzh
This review synthesizes recent large-scale multi-cohort studies revealing white matter microstructural abnormalities—especially free water increases—in limbic tracts as critical markers of cognitive decline in aging and Alzheimer’s di
A large multisite analysis (n=4,467) finds white matter free water (FW), especially in limbic tracts (cingulum, fornix), strongly associates with cross-sectional cognition and longitudinal decline; FW interacts with amyloid, APOE ε4, and gr
A secondary analysis of TRAILBLAZER‑ALZ 2 found that lower posttreatment amyloid plaque levels after donanemab correlate strongly with less clinical decline and reductions in plasma p‑tau217, p‑tau181, and GFAP over 76 weeks, supporting pla
Higher adherence to Mediterranean, MIND, and Recommended Food Score diets is linked to reduced risk of all-cause dementia and Alzheimer disease, highlighting diet as a modifiable factor in dementia prevention.
Enlarged perivascular spaces (EPVS) correlate with serum biomarkers of neuroinflammation and amyloid pathology and associate with cognitive impairment, supporting their role as early MRI markers for Alzheimer disease (AD) vascular contribut
