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Lorundrostat Lowers 24‑Hour Systolic Blood Pressure in Treatment‑Resistant Hypertension but Raises Hyperkalemia Concerns
Cardiologyaldosterone synthase inhibitorhyperkalemia

Lorundrostat Lowers 24‑Hour Systolic Blood Pressure in Treatment‑Resistant Hypertension but Raises Hyperkalemia Concerns

By MedXY|Dec 6, 2025

A randomized, placebo‑controlled trial found lorundrostat reduced 24‑hour systolic BP by ~7–8 mm Hg versus placebo in patients with uncontrolled, treatment‑resistant hypertension; notable rates of marked hyperkalemia occurred only in active

Baxdrostat: A Promising New Agent for Managing Uncontrolled and Resistant Hypertension
Cardiologyaldosterone synthase inhibitorBlood Pressure Control

Baxdrostat: A Promising New Agent for Managing Uncontrolled and Resistant Hypertension

By MedXY|Oct 7, 2025

Baxdrostat, a novel aldosterone synthase inhibitor, significantly reduces systolic blood pressure in patients with uncontrolled or resistant hypertension, offering a new therapeutic option with a favorable safety profile.

Lorundrostat: A New Frontier in the Management of Uncontrolled and Treatment-Resistant Hypertension
Cardiologyaldosterone synthase inhibitorclinical trial

Lorundrostat: A New Frontier in the Management of Uncontrolled and Treatment-Resistant Hypertension

By MedXY|Oct 2, 2025

Lorundrostat, an aldosterone synthase inhibitor, significantly reduced systolic blood pressure in adults with uncontrolled and treatment-resistant hypertension, demonstrating efficacy and safety as an adjunct therapy.

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