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Patterns and Implications of Local Regrowth After Neoadjuvant Chemoradiotherapy in Esophageal Cancer: Insights from the SANO Trial
Gastroenterology术前新辅助放化疗local regrowth

Patterns and Implications of Local Regrowth After Neoadjuvant Chemoradiotherapy in Esophageal Cancer: Insights from the SANO Trial

By MedXY|Aug 21, 2026

This study analyzes surgical specimens from the SANO trial, revealing that local regrowth after neoadjuvant chemoradiotherapy predominantly involves mucosa and submucosa and supports endoscopic monitoring in active surveillance, with surger

The Thyroid Cancer Modified Anxiety Scale (TC-MAX): A Novel Tool to Assess Cancer-Related Distress and Guide Patient-Centered Care
Diabetes & EndocrinologyPsychometricsAnxiety assessment

The Thyroid Cancer Modified Anxiety Scale (TC-MAX): A Novel Tool to Assess Cancer-Related Distress and Guide Patient-Centered Care

By MedXY|Aug 12, 2026

The TC-MAX is the first validated, disease-specific instrument measuring thyroid cancer-related anxiety, showing strong reliability and validity to inform treatment decisions and improve patient-centered care.

Most Patients With Uncertain Response After Neoadjuvant Chemoradiotherapy for Esophageal Cancer Still Harbor Residual Disease
General Surgeryactive surveillanceEsophagectomy

Most Patients With Uncertain Response After Neoadjuvant Chemoradiotherapy for Esophageal Cancer Still Harbor Residual Disease

By MedXY|May 26, 2026

In the SANO cohort, 85% of patients with uncertain post-chemoradiotherapy response had residual tumor at esophagectomy, supporting surgery for most, while highlighting a notable complete response subgroup among squamous cell carcinoma with

Long-Term Quality of Life Is Comparable Between Active Surveillance and Surgery for Low-Risk Papillary Thyroid Cancer
Diabetes & Endocrinologyactive surveillancepatient-reported outcomes

Long-Term Quality of Life Is Comparable Between Active Surveillance and Surgery for Low-Risk Papillary Thyroid Cancer

By MedXY|Mar 15, 2026

A prospective cohort study reveals that patients with low-risk papillary thyroid cancer experience similar quality of life outcomes at three years whether they choose active surveillance or immediate surgery, though those who crossover to s

Long-Term Survival Outweighs Short-Term Quality of Life: Why Esophagectomy Remains the Gold Standard for Esophageal Cancer Responders
General Surgeryactive surveillanceEsophagectomy

Long-Term Survival Outweighs Short-Term Quality of Life: Why Esophagectomy Remains the Gold Standard for Esophageal Cancer Responders

By MedXY|Mar 13, 2026

A decision analytical model reveals that while active surveillance offers short-term quality-of-life benefits, standard esophagectomy provides superior 5-year survival and quality-adjusted life-years (QALYs) for esophageal cancer patients a

Beyond Mandatory Resection: Active Surveillance Proves Safe for RAS-Positive Thyroid Nodules
Diabetes & Endocrinologyactive surveillanceendocrinology

Beyond Mandatory Resection: Active Surveillance Proves Safe for RAS-Positive Thyroid Nodules

By MedXY|Mar 6, 2026

A new study suggests that isolated RAS mutations in Bethesda III and IV thyroid nodules do not always require surgery. With a 34% malignancy rate and low growth incidence, active surveillance emerges as a viable, safe alternative for approp

Long-Term Survival vs. Short-Term Quality of Life: Deciding the Fate of Esophageal Cancer Responders
General Surgeryactive surveillanceEsophagectomy

Long-Term Survival vs. Short-Term Quality of Life: Deciding the Fate of Esophageal Cancer Responders

By MedXY|Jan 25, 2026

A decision analytical model based on the SANO trial suggests that while active surveillance offers short-term quality-of-life benefits, standard esophagectomy remains superior for maximizing long-term survival and quality-adjusted life-year

Active Surveillance Superior to Surgery for Quality of Life in Low-Risk Thyroid Cancer: Insights from a Global Meta-Analysis
newsactive surveillancepatient-reported outcomes

Active Surveillance Superior to Surgery for Quality of Life in Low-Risk Thyroid Cancer: Insights from a Global Meta-Analysis

By MedXY|Dec 28, 2025

A comprehensive meta-analysis demonstrates that patients with papillary thyroid microcarcinoma managed via active surveillance experience significantly better health-related quality of life and fewer treatment-related symptoms than those un

Metformin Fails to Delay Progression on Active Surveillance for Low‑Risk Prostate Cancer — Unexpected Signal in Obese Men
newsactive surveillancemetformin

Metformin Fails to Delay Progression on Active Surveillance for Low‑Risk Prostate Cancer — Unexpected Signal in Obese Men

By MedXY|Nov 23, 2025

The MAST phase III trial found no benefit of metformin (850 mg twice daily) versus placebo for delaying progression in men with low‑risk prostate cancer on active surveillance; a prespecified subgroup showed increased pathologic progression

Metformin Does Not Delay Progression on Active Surveillance for Low‑Risk Prostate Cancer — Unexpected Signal in Obesity
newsactive surveillancemetformin

Metformin Does Not Delay Progression on Active Surveillance for Low‑Risk Prostate Cancer — Unexpected Signal in Obesity

By MedXY|Nov 23, 2025

A randomized phase III trial (MAST) found metformin did not prolong progression‑free survival in men on active surveillance for low‑risk prostate cancer; an exploratory subgroup showed increased pathologic progression in obese patients.

Long-Term Durability of Active Surveillance in Small, Low-Risk Papillary Thyroid Cancer: Age-Related Outcomes and Clinical Implications
Oncologyactive surveillancelong-term outcomes

Long-Term Durability of Active Surveillance in Small, Low-Risk Papillary Thyroid Cancer: Age-Related Outcomes and Clinical Implications

By MedXY|Oct 4, 2025

Active surveillance is a durable management strategy for small, low-risk papillary thyroid cancer, especially among older adults who show significantly lower crossover rates to surgery.

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