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LC-MS/MS Redefines Accuracy in Congenital Adrenal Hyperplasia Newborn Screening: Reducing the False-Positive Burden
Diabetes & Endocrinology17-hydroxyprogesteroneCongenital Adrenal Hyperplasia

LC-MS/MS Redefines Accuracy in Congenital Adrenal Hyperplasia Newborn Screening: Reducing the False-Positive Burden

By MedXY|Mar 12, 2026

A prospective study of over 700,000 newborns demonstrates that LC-MS/MS significantly improves the positive predictive value (PPV) of CAH screening compared to traditional RIA, identifying specific steroid ratios that offer 100% PPV and red

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