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1. Alcohol drinking during adolescence induces distinct alterations in gut microbiota compositions and associated short-chain fatty acid (SCFA) profiles, leading to cognitive deficits in adulthood.
2. A targeted synbiotic intervention effectively restores gut microbiota balance, normalizes brain metabolite profiles, and reverses social and nonsocial cognitive impairments in mice.
3. Correlative networks suggest mechanistic links between specific gut bacteria, SCFAs, and brain metabolites such as β-hydroxybutyrate and glutamate, crucial for cognitive functions.
4. Synbiotic supplementation emerges as a promising therapeutic strategy to counteract long-term behavioral and molecular sequelae of adolescent alcohol binge consumption.
