Distinct Myeloid Landscapes Define Prognostic Niches in Extranodal NK/T-Cell Lymphoma

Highlight

• ENKTL exhibits two distinct myeloid-defined subgroups characterized by inflammatory or immune-quiescent macrophage programs.
• An NF-κB-activated, EBV-associated tumor subset colocalizes with inflammatory macrophages, forming a prognostic inflammatory niche.
• Tumor-myeloid cooperativity involves CCL- and IL1-mediated myeloid recruitment and self-reinforcement within the lymphoma microenvironment.
• The abundance of this inflammatory niche correlates with improved survival, offering insights for targeted immunotherapeutic strategies.

Study Background